Nasir Ahmad Salati
Dr Z.A.Dental College A.M.U., India
Title: Expression of Osteopontin in Potentially Malignant & Malignant
Biography
Biography: Nasir Ahmad Salati
Abstract
Osteopontin (OPN), a non-collagenous protein induces endothelial cell migration, acts in a subset of migratory pathways, plays a role in immune mechanisms and helps in regulatory pathways of the body. It acts as a ligand for the CD44 cell surface receptor sand stimulates chemotaxis of CD44-expressing cells. Several extracellular matrix proteins bind OPN in vitro, including fibronectin, osteocalcin and collagen types I, II, III,IV, and V, and may modulate cell-extracellular matrix interactions in vivo. As an early T lymphocyte activation protein 1 (Eta-1), it is believed to enhance Th1 but inhibit Th2 response. OPN increases invasiveness by inducing proteinases, promotes angiogenesis, increases tendency of cells towards metastasis, and acts in association with other growth factors to induce malignant properties. The purpose of present study is a) to evaluate its expression in oral lesions b) compare intensity of expression in these lesions, and c) to correlate the degree of expression of OPN with prognosis.
Study design: Purposive sampling of 120 cases of normal mucosa, mild dysplasia, severe dysplasia, OSMF and OSCCs were selected. The immune-positive reaction and score for each case was evaluated. Expression of OPN was correlated with clinical findings.
Results: In mild dysplasia & OLP, OPN expression was confined to basal cell layer with moderate intensity. The expression was strong throughout whole epithelium in severe dysplasia.OPN expression with moderate intensity in basal cell layers was observed in OSMF. The expression was very strong in OSCC.
Conclusion: Our study suggests potential role of Osteopontin in prognosis of oral lesions.